From its inception, the four-engine DC-8 embodied advanced aerodynamic and structural concepts, as well as internal systems designed for maximum service reliability, operational convenience and passenger comfort.

A capacity for improved power, payload and range capabilities was inherent in the DC-8 design. Four basic models were produced: the Series 10 through 50, in passenger, freighter and convertible freighter versions; and the Super 60 Series 61, 62 and 63, with freighter models of each. The last of 556 aircraft was delivered on May 13, 1972, marking the end of 15 years of production, at which time there were 48 operators in 28 nations.

Development of the Super 60 Series in 1965, with increased size, capacity and efficiency, demonstrated the capacity for growth in the DC-8 design. The Super 61 & 62 can carry up to 258 passengers. The Super 63, which combined the fuselage extension and payload capacity of the Super 61 with the long-range, aerodynamic and power plant improvements of the Super 62, carries a maximum capacity of 259 passengers and baggage 4,500 statute miles (7,242 km), or lesser loads even greater distances. The DC8 Super 63F/63CF is able to carry up to 116,000 pounds (52,617 kg) of freight.

The DC-8 Series 70 is a re-engined version of the popular Super 60 Series, substituting CFM56 engines for the latter's Pratt & Whitney engines. The result is an aircraft that retains the Super 60 operating weights, but with a longer range due to the newer, more fuel-efficient turbofans. The Series 70 was also able to meet later, more stringent noise regulation that were implemented in the 1980s.